TY  - JOUR
TI  - Cell death in the developing vertebrate retina 
AU  - Vecino, Elena
AU  - Hernández, María
AU  - García, Mónica
T2  - The International Journal of Developmental Biology
AB  - Programmed cell death occurs naturally, as a physiological process, during the embryonic development of multicellular organisms. In the retina, which belongs to the central nervous system, at least two phases of cell death have been reported to occur during development. An early phase takes place concomitant with the processes of neurogenesis, cell migration and cell differentiation. A later phase affecting mainly neurons occurs when connections are established and synapses are formed, resulting in selective elimination of inappropriate connections. This pattern of cell death in the developing retina is common among different vertebrates. However, the timing and magnitude of retinal cell death varies among species. In addition, a precise regulation of apoptosis during retinal development has been described. Factors such as neurotrophins, among many others, and electrical activity influence the survival of retinal cells during the course of development. In this paper, we present a summary of these different aspects of programmed cell death during retinal development, and examine how these differ among different species. 
PY  - 2004
DO  - 10.1387/ijdb.041891ev
VL  - 48
IS  - 8-9
SP  - 965
EP  - 974
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041891ev
Y2  - 2024/04/29/02:17:53
ER  -