TY  - JOUR
TI  - The human T cell immune response to Epstein-Barr virus
AU  - Landais, Elise
AU  - Saulquin, Xavier
AU  - Houssaint, Elisabeth
T2  - The International Journal of Developmental Biology
AB  - The Epstein-Barr virus (EBV) is a gamma-herpes virus which establishes latent, life-long infection in more than 95% of the human adult population. Despite its growth transforming capacity, most carriers control EBV associated malignacies efficiently and remain free of EBV+ tumors. Though EBV is controlled by a potent immune response, this virus uses latency to persist in vivo. This review summarizes work which has been done to characterize T cell responses to EBV. The CD8 T cell responses are rather well characterized and have been shown by several groups to be highly focused towards early lytic antigens. Much less is known about CD4 T cell epitopes, due to the small size of the CD4 compartment. However,  recent data indicate a control of lytic and latent cycles of EBV by specific CD4+ T cells. A clear understanding of the T cell response to EBV is important with a view to developing immunotherapies for the virus and its related malignancies.
PY  - 2005
DO  - 10.1387/ijdb.041947el
VL  - 49
IS  - 2-3
SP  - 285
EP  - 292
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041947el
Y2  - 2024/05/05/07:48:35
ER  -