TY  - JOUR
TI  - On the transition from the meiotic to mitotic cell cycle during early mouse development
AU  - Kubiak, JacekZ.
AU  - Ciemerych, MariaA.
AU  - Hupalowska, Anna
AU  - Sikora-Polaczek, Marta
AU  - Polanski, Zbigniew
T2  - The International Journal of Developmental Biology
AB  - Here, we outline the mechanisms involved in the regulation of cell divisions during oocyte maturation and early cleavages of the mouse embryo. Our interest is focused on the regulation of meiotic M-phases and the first embryonic mitoses that are differently tuned and are characterized by specifically modified mechanisms, some of which have been recently identified. The transitions between the M-phases during this period of development, as well as associated changes in their regulation, are of key importance for both the meiotic maturation of oocytes and the further development of the mammalian embryo. The mouse is an excellent model for studies of the cell cycle during oogenesis and early development. Nevertheless, a number of molecular mechanisms described here were discovered or confirmed during the study of other species and apply also to other mammals including humans.
PY  - 2008
DO  - 10.1387/ijdb.072337jk
VL  - 52
IS  - 2-3
SP  - 201
EP  - 217
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072337jk
Y2  - 2024/05/02/23:06:11
ER  -