TY  - JOUR
TI  - A twist of insight - the role of Twist-family bHLH factors in development 
AU  - Barnes, RalstonM.
AU  - Firulli, AnthonyB.
T2  - The International Journal of Developmental Biology
AB  - Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential developmental programs. Twist-family bHLH proteins function by dimerizing with other bHLH members and binding to cis- regulatory elements, called E-boxes. While Twist-family members may simply exhibit a preference in terms of high-affinity binding partners, a complex, multilevel cascade of regulation creates a dynamic role for these bHLH proteins. We summarize in this review information on each Twist-family member concerning expression pattern, function, regulation, downstream targets, and interactions with other bHLH proteins. Additionally, we focus on the phospho-regulatory mechanisms that tightly control posttranslational modification of Twist-family member bHLH proteins.
PY  - 2009
DO  - 10.1387/ijdb.082747rb
VL  - 53
IS  - 7
SP  - 909
EP  - 924
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/082747rb
Y2  - 2024/05/05/16:47:03
ER  -