TY  - JOUR
TI  - <I>Sox17</I>-dependent gene expression and early heart and gut development in <I>Sox17</I>-deficient mouse embryos
AU  - Pfister, Sabine
AU  - Jones, VanessaJ.
AU  - Power, Melinda
AU  - Truisi, GermaineL.
AU  - Khoo, Poh-Lynn
AU  - Steiner, KirstenA.
AU  - Kanai-Azuma, Masami
AU  - Kanai, Yoshiakira
AU  - Tam, PatrickP.L.
AU  - Loebel, DavidA.F.
T2  - The International Journal of Developmental Biology
AB  - Sox17 is a transcription factor that is required for maintenance of the definitive endoderm in mouse embryos. By expression profiling of wild-type and mutant embryos and Sox17-overexpressing hepatoma cells, we identified genes with Sox17-dependent expression. Among the genes that were up-regulated in Sox17-null embryos and down-regulated by Sox17 expressing HepG2 cells is a set of genes that are expressed in the developing liver, suggesting that one function of Sox17 is the repression of liver gene expression, which is compatible with a role for Sox17 in maintaining the definitive endoderm in a progenitor state. Consistent with these findings, Sox17-/- cells display a diminished capacity to contribute to the definitive endoderm when transplanted into wild-type hosts. Analysis of gene ontology further revealed that many genes related to heart development were downregulated in Sox17-null embryos. This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal. 
PY  - 2011
DO  - 10.1387/ijdb.103158sp
VL  - 55
IS  - 1
SP  - 45
EP  - 58
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/103158sp
Y2  - 2024/04/28/17:00:19
ER  -