Int. J. Dev. Biol. 59: 149 - 158 (2015)

https://doi.org/10.1387/ijdb.150037fs

Vol 59, Issue 1-2-3

Special Issue: Cell Death in Development & Tumors

Regulated cell death in diagnostic histopathology

Published: 2 September 2015

Faruk Skenderi¹, Semir Vranic¹ and Ivan Damjanov*^,2

¹Department of Pathology, University of Sarajevo Clinical Center, Sarajevo, Bosnia and Herzegovina and ²Department of Pathology and Laboratory Medicine, University of Kansas School of Medicine, Kansas City, Kansas, USA

Abstract

Regulated cell death (RCD) is a controlled cellular process, essential for normal development, tissue integrity and homeostasis, and its dysregulation has been implicated in the pathogenesis of various conditions including developmental and immunological disorders, neurodegenerative diseases, and cancer. In this review, we briefly discuss the historical perspective and conceptual development of RCD, we overview recent classifications and some of the key players in RCD; finally we focus on current applications of RCD in diagnostic histopathology.

Keywords

regulated cell death, programmed cell death, apoptosis, histopathology, diagnostic markers